MBE: AINE IM vs VO: diferència entre les revisions

   Administration, Oral

#Aquesta <cite>PM2</cite>:

##OBJECTIVE: There is a commonly held belief among health care providers that patients respond better to parenteral nonsteroidal anti-inflammatory drugs (NSAIDs) than to oral forms by virtue of the patients' belief that getting an injection means they are receiving "stronger" medicine. To the authors' knowledge, this effect has never been adequately documented in the literature. The objective of this study was to compare the effects of a placebo analgesic injection vs placebo oral analgesia on patients with acute musculoskeletal pain.  

##RESULTS: Sixty-four patients completed the study protocol. The VAS scores between groups did not differ significantly at baseline or at each subsequent interval (p = 0.86).  

##CONCLUSIONS: These results contradict the belief that parenteral medications confer a selective placebo effect stemming from patients' beliefs regarding route of administration and efficacy. Therefore, the routine use of IM administration of NSAIDs for suspected enhanced analgesia appears unwarranted.

#I aquesta <cite>PM1</cite>:

##OBJECTIVE: To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain.  

*<cite>TD4</cite>: estudi randomitzat. N=14. Les injeccions intramusculars tenen una absorció erràtica mirant les concentracions del fàrmac en sang.

*<cite>TD5</cite>: '''revisió sistemàtica d'assajos clínics. N=2225. Excepte en el còlic nefrític no hi ha evidència que cap de les rutes sigui millor que la oral'''.  

*<cite>PM1</cite>: anàlisi retrospactiu. N=?. El ketorolak IM no ha demostrat ser millor que l'ibuprofè VO.